A study on the development of scaffold fabrication using citric acid polyester – nanohydroxyapatite composite

ABSTRACT. Nano hydroxyapatite (n-HAp) and its composites have shown a great development in the field of tissue regeneration controlled drug delivery due to good biocompatibility bioactivity behavior. Furthermore, HAp-based nanocomposites enhance mechanical properties. These synthetic HAp can also be tailored fabricate scaffold with porosity which facilitate growth cell engineering. In this paper, we focus on synthesis nano by sol-gel method. The synthesized powders were calcined at 500 oC characterized FT-IR, XRD TEM. We described citric acid-based polyester melt polycondensation method without adding catalyst. monomers used acid, 1,6-hexane diol sebacic acid. corresponding n-HAp/polyester composite potential application soft structures nanocomposite studied FT-IR 1H NMR spectral studies. thermal properties polyester, cytotoxicity activity (MTT assay) using vero cells studied. Porous HAp/Polyester was fabricated solvent-casting particulate leaching technique is useful engineering applications. SEM TEM studies carried out for HAp, scaffold.
 
 KEY WORDS: Cytotoxicity, Polycondensation, Sol-gel, Solvent-casting, Tissue engineering
 Bull. Chem. Soc. Ethiop. 2022, 36(4), 923-934. DOI: https://dx.doi.org/10.4314/bcse.v36i4.17